Vagal nerve stimulation in chronic heart failure
نویسندگان
چکیده
منابع مشابه
Vagal nerve stimulation in chronic heart failure: an antiinflammatory intervention?
Failure: An Antiinflammatory Intervention? To the Editor: Li et al1 recently reported that vagal nerve stimulation improved survival in otherwise untreated rats with heart failure secondary to left coronary artery ligation. Although this finding is indeed intriguing and of potential therapeutic importance, the authors are understandably speculative about the possible mechanisms underlying this ...
متن کاملVagal nerve stimulation in heart failure.
It has been estimated that the prevalence of heart failure with a reduced ejection fraction exceeds 20 million patients worldwide— about 2% of the general population in the Western world—and that the annual incidence is . 2 million patients per year. The mortality of heart failure exceeds that of many malignancies. Significant healthcare improvements have been made with regard to pharmaceutical...
متن کاملShort-term vagal nerve stimulation improves left ventricular function following chronic heart failure in rats
Increasing numbers of animal and clinical investigations have demonstrated the effectiveness of long-term electrical vagal nerve stimulation (VNS) on chronic heart failure (CHF). The present study investigated the effects of short-term VNS on the hemodynamics of cardiac remodeling and cardiac excitation-contraction coupling (ECP) in an animal model of CHF following a large myocardial infarction...
متن کاملChronic vagal nerve stimulation improves baroreflex neural arc function in heart failure rats.
We tested whether 6-wk vagal stimulation (VS) treatment improved open-loop baroreflex function in rats after myocardial infarction (MI). The following three groups of Sprague-Dawley rats were examined: normal control (NC, n = 9), MI with no treatment (MI-NT, n = 8), and MI treated with VS (MI-VS, n = 7). Under anesthesia, a stepwise input ranging from 60 to 180 mmHg was imposed on isolated caro...
متن کاملVagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats.
BACKGROUND Diminished cardiac vagal activity and higher heart rate predict a high mortality rate of chronic heart failure (CHF) after myocardial infarction. We investigated the effects of chronic electrical stimulation of the vagus nerve on cardiac remodeling and long-term survival in an animal model of CHF after large myocardial infarction. METHODS AND RESULTS Two weeks after the ligation of...
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ژورنال
عنوان ژورنال: Nature Reviews Cardiology
سال: 2016
ISSN: 1759-5002,1759-5010
DOI: 10.1038/nrcardio.2016.67